01 / 09

TriStar Technology Group

Quality biospecimens
& data for precision medicine

FFPE surgical samples — Primary tumors, Mets, Normal (non-malignant) tissues

Donors from UK, Italy, France with informed consent & ethics approval

Clinical follow-up data including treatment, response, OS & PFS

Responders & non-responders to SOC treatment including CKI/IO

Mutations, fusions and other diagnostic markers

Expert IHC capabilities — over 100 optimized assays

02 / 09

Advanced disease (Stage III/IV) surgical samples

Tumor types

NSCLC CRC Ovarian Prostate (mCRPC) Breast Gastric Endometrial Pancreatic ADC Bladder (UC) Melanoma RCC HCC Esophageal Head & Neck SCC

Follow-up data

Treatment Response OS/PFS

Mutations*

KRAS NRAS EGFR ALK BRAF BRCA MET HRD

* as available from donor records

IHC markers

ER/PR Her2 MMR MSI PDL-1 TROP2 Nectin4 B7H3 B7H4 DLL3 p16 p53

HBS formats

FFPE TMA Slides
03 / 09

Sequentially collected (longitudinal) surgical samples from the same donor

Tumor types

NSCLC CRC Ovarian Head & Neck SCC Breast Gastric Endometrial RCC Bladder (UC) Melanoma

Follow-up data

Treatment Response OS/PFS

Mutations*

KRAS NRAS EGFR ALK BRAF BRCA MET HRD

* as available from donor records

IHC markers

ER/PR Her2 MMR MSI PDL-1 TROP2 Nectin4 B7H3 B7H4 DLL3 p16 p53

HBS formats

FFPE TMA Slides
04 / 09

Primary & matched distant metastases (surgical samples)

Tumor types

NSCLC CRC Ovarian Head & Neck SCC Breast Gastric Endometrial Bladder (UC) Melanoma RCC

Examples of metastatic sites

Lymph nodes Bone Liver Lung Brain Peritoneal

*Mets only (without matched primary) samples available

Follow-up data

Treatment Response OS/PFS

Mutations*

KRAS NRAS EGFR ALK BRAF BRCA MET HRD

*As available from donor records.

IHC markers

ER/PR Her2 MMR MSI PDL-1 TROP2 Nectin4 B7H3 B7H4 DLL3 p16 p53

HBS formats

FFPE Slides TMA Block or slides
05 / 09

Pre & Post standard of care (SOC) treatment surgical samples

Includes a sub-set of donor matched sets.

Tumor types

NSCLC CRC Ovarian Head & Neck SCC Breast Gastric Endometrial Pancreatic ADC Bladder (UC) Melanoma RCC

Follow-up data

Treatment Response OS/PFS

Mutations*

KRAS NRAS EGFR ALK BRAF BRCA MET HRD

* as available from donor records

IHC markers

ER/PR Her2 MMR MSI PDL-1 TROP2 Nectin4 B7H3 B7H4 DLL3 p16 p53

HBS formats

FFPE TMA Slides
06 / 09

Pre & Post IO (Pembro/Nivo) treatment surgical samples

1st line SOC chemo, 2nd line IO. Includes a sub-set of donor matched sets.

Tumor types

NSCLC RCC Head & Neck SCC Melanoma

Follow-up data

Treatment Response OS/PFS

Mutations*

KRAS NRAS EGFR ALK BRAF BRCA MET HRD

* as available from donor records

IHC markers

ER/PR Her2 MMR MSI PDL-1 TROP2 Nectin4 B7H3 B7H4 DLL3 p16 p53

HBS formats

FFPE Slides TMA Block or slides
07 / 09
100+ Optimized assays
Developed for
  • Ventana Benchmark
  • Dako Auto stainers
3 Medical pathologists X+ combined years in pharma
Services
  • IHC
  • RNAScope
  • NGS
  • RNA-Seq
  • Digital Spatial Profiling
  • Digital image analysis
09 / 09

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