Example HBS Cohorts.

Gender Date Of diagnosis Age At Diagnosis

Specimen Histological Diagnosis

Staging Grading Info Provided For Resection Margins Clear p T p N p M c M TNM Stage Grade Staging Criteria

Any Immunotherapy Specimen Treatment Subgrouping Specimen Is A recurrence Specimen Surgery Date Specimen Surgery Specimen Tumour Site

Primary Surgery Date Primary Tumour Site

Matched Met1 Site Matched Met1 Surgery Date Matched Met1 Treatment Subgrouping Matched Met2 Site Matched Met2 Surgery Date Matched Met2 Treatment Subgrouping Matched Met3 Block Number Matched Met3 Site Matched Met3 Surgery Date Matched Met3 Treatment Subgrouping Matched Met4 Block Number Matched Met4 Site Matched Met4 Surgery Date Matched Met4 Treatment Subgrouping

Any Neoadjuvant Therapy TTE Neoadjuvant Tx1 Start Date TTE Neoadjuvant Tx1 End Date

Adjuvant Tx1 Adjuvant Tx1 Agent Tumour Response Adjuvant Tx1 Adjuvant Tx2 Adjuvant Tx2 Agent Adjuvant Tx15 Agent Tumour Response Adjuvant Tx15

Subsequent Tx1 Subsequent Tx1 Agent Tumour Response Subsequent Tx1 Subsequent Tx2 Subsequent Tx2 Agent Tumour Response Subsequent Tx2 Subsequent Tx3 Subsequent Tx3 Agent Tumour Response Subsequent Tx3

Sites recurrence Progression 1

Current Status Death Tumour Related Cause Of Death Comments Clinical Team

TTE Specimen Surgery Date TTE Primary Surgery Date TTE Matched Met1 Surgery Date TTE Matched Met2 Surgery Date TTE Matched Met3 Surgery Date TTE Matched Met4 Surgery Date TTE Matched Met5 Surgery Date TTE Matched Normal Tissue Surgery Date TTE Adjuvant Tx1 Start Date TTE Adjuvant Tx1 End Date TTE Date recurrence Progression1 TTE Subsequent Tx1 Start Date TTE Subsequent Tx1 End Date TTE recurrence PFS TTE Death OS PFS TTE Date Last Followup PFS TTE Date Last Seen OS TTE OS Months TTE PFS Months

Event recurrence Progression Event Cancer Death Event Death All Causes Event recurrence Or Cancer Death

Stage At diagnosis